Name:
Dr Kai-Keen Shiu
Post-nominal Letters:
PhD, FRCP
Job Title:
Consultant in the Gastrointestinal Oncology Unit and Clinical Lead for the Cancer of Unknown Primary Service
Organisation / Company:
University College London Hospital NHS Foundation Trust
Biography:
Dr Kai-Keen Shiu PhD FRCP is a Consultant in the Gastrointestinal Oncology Unit and Clinical Lead for the Cancer of Unknown Primary Service at University College London Hospital NHS Foundation Trust and Honorary Associate Professor at the UCL Cancer Institute.
He qualified at Guys and St Thomas’ Medical School, training in medical oncology at the Royal Free Hospital and UCLH. He completed his PhD in integrative genomic profiling of cancer at the Institute of Cancer Research and the Royal Marsden Hospital with Professor Alan Ashworth. He also attained a post-CCT research fellowship at the MRC Clinical Trials Unit at UCL. He is a member of ASCO, ESMO and the Association of Cancer Physicians UK.
Dr Shiu is an active clinical triallist and is the UK Chief Investigator or Principal Investigator for several GI immuno-oncology trials including KEYNOTE 811 and 859, MATTERHORN, KEYNOTE 177, LEAP 17, KEYSTEP-008, BNT122-01, NOUS-209-01, and Chief Investigator of NEOPRISM-CRC; an investigator-initiated trial of neoadjuvant immunotherapy for patients with operable MMR deficient bowel cancer. He is also the UK Chief Investigator for CUPISCO, a 1st line Phase 2 randomised molecular guided therapy CUP trial.
His translational research interests include targeted treatments and immunotherapy for GI malignancies and CUP, as well as patients with young onset colorectal cancer. He is Chair of the NCRI MUO-CUP Workstream and a member of the NCRI Colorectal Advanced and Adjuvant Disease Subgroup. He is a collaborator in the PEACE (Posthumous tissuE donAtion in CancEr) study, and a member of the Gastrointestinal Oncology and CUP subgroups at the UCL Cancer Institute/Francis Crick Institute. He is the Principal Investigator of the UCL/UCLH Gastrointestinal Cancer and CUP Translational Research Biobank.